I shoot with Canon. I always pre-cull using Canon's DPP before importing to LrC. I do that right off the card and delete unwanted or unusable files. DPP's downsizing algorithm for 'fit to screen' display is very good - contrasty which creates the illusion of sharpness. Plus it is free.
With LrC's new Adaptive ISO presets Texture, Clarity, Dehaze, Sharpening, Detail, Masking and NR auto apply at import based on each files ISO. Lens Corrections and CA also auto apply at import.
Currently I only use Topaz Denoise AI - if necessary. While Topaz suggest to turn Sharpening and NR to zero I reduce those by 50% for each specific ISO. I find that applying some Sharpening and NR makes Topaz work less harder minimizing occasional odd artifacts with noisier files. I reduce Sharpening, Detail and NR, I don't reduce Masking because I think it makes a difference. I have a presets for the ISO ranges to speed things up.
I also have Topaz Sharpen AI but rarely use it. I got it for the Stabilize feature and use it if I really need that file. For my hobby shooting if I didn't get it sharp I don't use it.
That being said I hope Adobe comes out with NR Sensei one day so I can stop using 3rd party NR products for those tougher jobs.