WesternGuy-
Victoria is right on the first step - I'd try the Add/Remove Programs dialog in the Control Panel first.
If uninstalling stuff there doesn't work, you can always access the Device Manager and uninstall it from there. I'm not on Windows 7 yet, but it's typically accessed by right-clicking on My Computer, selecting properties, Hardware Tab, Device Manager. On my current machine at work (Windows XP), the Wacom stuff shows up under Human Interface Devices. I can right-click on the Wacom drivers in there and choose to uninstall them.
As far as the tablet itself, some basic functions (moving the pen around, touching the pen to the tablet to click, etc.) will work without a driver - most computers will recognize it as a basic input device. You need the drivers to do the more advanced stuff (map it to your screen in the most efficient way, make it left-handed if desired, customize the pen buttons, etc.).