I'm using it with the small 4x6 one(Graphire4). I can't say I've experimented with it too much, other than it more or less works. As far as optimizing the setup, I haven't even tried. I don't have a great deal of tablet experience, and my physical desk setup isn't truly amenable to using it ergonomically. I periodically play with it, but end up with a sore forearm, and drop back to using the mouse, with which I'm far more dextrous.
I blame some of that on the small size of the tablet. I'm sure I'd do better with a larger one.