"are you able to do in a step by step manual way"
I noodled that puzzle on my drive home. You can indeed do this using multiple steps with the Library Filter bar:
1. In the Catalog panel, click All Photographs.
2. In the Library Filter bar, click Metadata and configure the metadata browser to have just the Keyword column.
3. In the Keyword column, select the keywords A, B, C:
At this point, only photos containing at least A, B, or C are shown. Those photos may contain other keywords.
4. Select all the displayed photos and add them to the Quick Collection.
5. In the Catalog panel, click Quick Collection.
6. In the metadata browser's Keyword column, select all the keywords
except A, B, and C. You can do this quickly for large keyword lists by clicking the first keyword in the column, shift-clicking the last keyword, and then Cmd/Ctrl-clicking A, B, C:
At this point, the photos displayed are those with at least one of A, B, or C
and some keyword other than A, B, C.
7. Select all the displayed photos and do Photo > Remove From Quick Collection.
Now the photos left in Quick Collection are exactly those that have one of A, B, or C but no other keyword.
This method is pretty klutzy for very large keyword lists, since it can be painful to scroll the Keyword column to find the desired keywords.